设为首页 电子邮箱 联系我们

本刊最新招聘信息请见“通知公告”!  本刊投稿系统试运行中,欢迎投稿!如投稿有问题,可直接将稿件发送至zgyy8888@163.com

 
网站首页杂志简介编委会成员本刊稿约编辑部照片过刊目录广告合作读者论坛联系我们
位置:首页 >> 电子期刊 >> 正文
氟西汀药理作用的研究进展
作者:刘野 李天佐 
单位:100026 首都医科大学附属北京妇产医院麻醉科(刘野) 100038 首都医科大学附属北京世纪坛医院麻醉科(李天佐) 
关键词:氟西汀 抑郁症 神经保护 抗炎 抗肿瘤 
分类号:R 97
出版年,卷(期):页码:2017,12(11):1751-1753
摘要:

【摘要】氟西汀是一种5-羟色胺再摄取抑制剂,能选择性抑制突触前膜对5-羟色胺的再摄取,从而增加突触间隙5-羟色胺水平,达到治疗抑郁症的目的。然而随着对抑郁症发病机制研究的不断深入,氟西汀还被发现具有神经保护、抗炎以及抗肿瘤作用。本文对近年来有关氟西汀神经保护、抗炎以及抗肿瘤作用的研究进展进行综述。

Advances of pharmacological effects of fluoxetine
Liu Ye, Li Tianzuo
Department of Anesthesiology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China(Liu Y); Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China(Li TZ)
Corresponding author: Li Tianzuo, Email: trmzltz@163.com
【Abstract】Fluoxetine is one kind of serotonin (5-HT) reuptake inhibitors which can selectively inhibit reuptake of 5-HT in synaptic membrane and increase the level of 5-HT in synaptic interstitial space. With further researches on mechanisms of fluoxetine in treatment of depression, its neuroprotective, anti-inflammatory and anti-tumor effects have been proved. This paper summarized pharmacological effects of fluoxetine.
【Key words】Fluoxetine;Depression;Neuroprotection;Anti-inflammation;Anti-tumor

基金项目:
作者简介:
参考文献:

[1]高国庆,肖玲,王晓萍,等.氟西汀与艾司西酞普兰对大鼠抑郁样行为及海马BDNF基因表达的影响[J].中华行为医学与脑科学杂志,2015,24(10):865-868. DOI: 10.3760/cma.j.issn.1674-6554.2015.10.001.Gao GQ, Xiao L, Wang XP, et al. Effects of fluoxetine and escitalopram on depressive-like behavior and hippocampal BDNF gene expression in adult rats[J]. Chinese Journal of Behavioral Medicine and Brain Science, 2015,24(10):865-868. DOI: 10.3760/cma.j.issn.1674-6554.2015.10.001.
[2]康平,朱海清,胡军.脑梗死后抑郁症药物治疗及其对神经功能康复影响的临床观察[J].中国医药,2007,2(9):543-544. DOI: 10.3760/cma.j.issn.1673-4777.2007.09.015.
Kang P, Zhu HQ, Hu J. Clinical observation of drug treatment of depression after cerebral infarction and its influence on nerve function rehabilitation[J]. China Medicine, 2007,2(9):543-544. DOI: 10.3760/cma.j.issn.1673-4777.2007.09.015.
[3]Chang YC, Tzeng SF, Yu L, et al. Early-life fluoxetine exposure reduced functional deficits after hypoxic-ischemia brain injury in rat pups[J]. Neurobiol Dis, 2006,24(1):101-113. DOI: 10.1016/j.nbd.2006.06.001.
[4]Ma J, Gao Y, Jiang L, et al. Fluoxetine attenuates the impairment of spatial learning ability and prevents neuron loss in middle-aged APPswe/PSEN1dE9 double transgenic Alzheimer′s disease mice[J]. Oncotarget, 2017,8(17):27676-27692. DOI: 10.18632/oncotarget.15398.
[5]Sachs BD, Caron MG. Chronic fluoxetine increases extra-hippocampal neurogenesis in adult mice[J]. Int J Neuropsychopharmacol, 2015,18(4):pyu029. DOI: 10.1093/ijnp/pyu029.
[6]Guirado R, Perez-Rando M, Sanchez-Matarredona D, et al. Chronic fluoxetine treatment alters the structure, connectivity and plasticity of cortical interneurons[J]. Int J Neuropsychopharmacol, 2014,17(10):1635-1646. DOI: 10.1017/S1461145714000406.
[7]Young EA, Altemus M, Lopez JF, et al. HPA axis activation in major depression and response to fluoxetine: a pilot study[J]. Psychoneuroendocrinology, 2004,29(9):1198-1204. DOI: 10.1016/j.psyneuen.2004.02.002.
[8]Henneberger C, Papouin T, Oliet SH, et al. Long-term potentiation depends on release of D-serine from astrocytes[J]. Nature, 2010,463(7278):232-236. DOI: 10.1038/nature08673.
[9]Bath KG, Jing DQ, Dincheva I, et al. BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity[J]. Neuropsychopharmacology, 2012,37(5):1297-1304. DOI: 10.1038/npp.2011.318.
[10]Karpova NN, Pickenhagen A, Lindholm J, et al. Fear erasure in mice requires synergy between antidepressant drugs and extinction training[J]. Science, 2011,334(6063):1731-1734. DOI: 10.1126/science.1214592.
[11]Avitsur R. Prenatal fluoxetine modifies the behavioral and hormonal responses to stress in male mice: role for glucocorticoid insensitivity[J]. Behav Pharmacol, 2017,28(5):345-355. DOI: 10.1097/FBP.0000000000000303.
[12]Katafuchi T, Duan S, Take S, et al. Cytokine-induced suppression of medial preoptic neurons: mechanisms and neuroimmunomodulatory effects[J]. Ann N Y Acad Sci, 2009(1153):76-81. DOI: 10.1111/j.1749-6632.2008.03963.x.
[13]Velázquez YF, Nacheva PM. Biodegradability of fluoxetine, mefenamic acid, and metoprolol using different microbial consortiums[J]. Environ Sci Pollut Res Int, 2017,24(7):6779-6793. DOI: 10.1007/s11356-017-8413-y.
[14]Müller N, Schwarz MJ. The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression[J]. Mol Psychiatry, 2007,12(11):988-1000. DOI: 10.1038/sj.mp.4002006.
[15]Maes M, Kenis G, Kubera M, et al. The negative immunoregulatory effects of fluoxetine in relation to the cAMP-dependent PKA pathway[J]. Int Immunopharmacol, 2005,5(3):609-618. DOI: 10.1016/j.intimp.2004.11.008.
[16]Azad N, Rojanasakul Y, Vallyathan V. Inflammation and lung cancer: roles of reactive oxygen/nitrogen species[J]. J Toxicol Environ Health B Crit Rev, 2008,11(1):1-15. DOI: 10.1080/10937400701436460.
[17]Laugeray A, Launay JM, Callebert J, et al. Chronic treatment with the IDO1 inhibitor 1-methyl-D-tryptophan minimizes the behavioural and biochemical abnormalities induced by unpredictable chronic mild stress in mice-comparison with fluoxetine[J]. PLoS One, 2016,11(11):e0164337. DOI: 10.1371/journal.pone.0164337.
[18]Peer D, Margalit R. Fluoxetine and reversal of multidrug resistance[J]. Cancer Lett, 2006,237(2):180-187. DOI: 10.1016/j.canlet.2005.06.003.
[19]Peer D, Dekel Y, Melikhov D, et al. Fluoxetine inhibits multidrug resistance extrusion pumps and enhances responses to chemotherapy in syngeneic and in human xenograft mouse tumor models[J]. Cancer Res, 2004,64(20):7562-7569. DOI: 10.1158/0008-5472.CAN-03-4046.
[20]Zhou T, Duan J, Wang Y, et al. Fluoxetine synergys with anticancer drugs to overcome multidrug resistance in breast cancer cells[J]. Tumour Biol, 2012,33(5):1299-1306. DOI: 10.1007/s13277-012-0377-4.
[21]Zhu XL, Yang WC, Yu NX, et al. Computational simulations of structural role of the active-site W374C mutation of acetyl-coenzyme-A carboxylase: multi-drug resistance mechanism[J]. J Mol Model, 2011,17(3):495-503. DOI: 10.1007/s00894-010-0742-4.
[22]Elumalai R, Patil S, Maliyakkal N, et al. Protamine-carboxymethyl cellulose magnetic nanocapsules for enhanced delivery of anticancer drugs against drug resistant cancers[J]. Nanomedicine, 2015,11(4):969-981. DOI: 10.1016/j.nano.2015.01.005.
[23]Kannen V, Hintzsche H, Zanette DL, et al. Antiproliferative effects of fluoxetine on colon cancer cells and in a colonic carcinogen mouse model[J]. PLoS One, 2012,7(11):e50043. DOI: 10.1371/journal.pone.0050043.
[24]Kannen V, Marini T, Turatti A, et al. Fluoxetine induces preventive and complex effects against colon cancer development in epithelial and stromal areas in rats[J]. Toxicol Lett, 2011,204(2-3):134-140. DOI: 10.1016/j.toxlet.2011.04.024.
[25]Koh SJ, Kim JM, Kim IK, et al. Fluoxetine inhibits NF-κB signaling in intestinal epithelial cells and ameliorates experimental colitis and colitis-associated colon cancer in mice[J]. Am J Physiol Gastrointest Liver Physiol, 2011,301(1):G9-19. DOI: 10.1152/ajpgi.00267.2010.

服务与反馈:
文章下载】【加入收藏
copyright © 《中国医药》杂志编辑部
地址:北京市朝阳区安贞路2号首都医科大学附属北京安贞医院北楼二层    
电话:010-64456116     传真:010-64428528    邮编:100029
网址:www.chinamedicinej.com     Email: zgyy8888@163.com
当您在使用本网站投稿遇到困难时,请直接将稿件投送到编辑部邮箱zgyy8888@163.com
 京ICP备10041176号-1