2018 年第 9 期 第 13 卷

益气复生方对胃癌患者代谢产物的影响及其临床治疗效果

Effect of Yiqi Fusheng recipe on metabolites in patients with gastric cancer

作者：何娜娜靳瑾陈音

英文作者：

单位：830000乌鲁木齐，新疆医科大学附属中医医院肿瘤一科

英文单位：

关键词：胃肿瘤；益气复生方；氨基酸类；脂类代谢

英文关键词：

• 摘要：

• 【摘要】目的    探讨益气复生方对胃癌患者代谢产物的影响及其临床治疗效果。方法    选取2016年1月至2017年1月在新疆医科大学附属中医医院接受治疗的88例胃癌患者，将所有患者完全随机分为对照组（43例）与观察组（45例）。对照组患者接受奥沙利铂联合卡培他滨治疗，观察组在对照组基础上服用益气复生方治疗，4周为1个治疗周期，2组患者在接受3个周期治疗后检测血清代谢指标，并评价疗效。结果    治疗3个周期后，观察组患者血清半胱氨酸、丝氨酸、甘氨酸、N-乙酰谷氨酸、十六碳烯酸、庚酸水平明显高于对照组，胱氨酸、天冬氨酸、3-羟基丁酸、α-亚麻酸水平明显低于对照组，差异均有统计学意义（均P＜0.05）。观察组患者治疗有效率明显高于对照组［33.3%（15/45）比25.6%（11/43）］（P=0.035）；2组患者疾病控制率差异无统计学意义(P=0.054)。观察组患者的0～Ⅰ级贫血、白细胞减少、中性粒细胞减少、肾功能损害和恶心呕吐发生率均明显低于对照组［35.6%（16/45）比55.8%（24/43）、31.1%（14/45）比48.8%（21/43）、28.9%（13/45）比39.5%（17/43）、6.7%（3/45）比14.0%（6/43）、17.8%（8/45）比34.9%（15/43）］，差异均有统计学意义（均P＜0.05）。2组患者血小板减少和肝功能损害发生情况差异均无统计学意义(均P＞0.05)。结论    益气复生方可调节胃癌患者氨基酸类和脂类物质代谢，减轻患者的不良反应，对胃癌患者有良好的治疗效果。

• 【Abstract】Objective    To observe the effect of Yiqi Fusheng recipe on metabolites in patients with gastric cancer. Methods    A total of 88 patients admitted in Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University from January 2016 to January 2017 were randomly divided into control group（n＝43） and observation group（n＝45）. The control group was treated with oxaliplatin and capecitabine; the observation group was treated with Yiqi Fusheng recipe on the basis of control group; 1 course of treatment was 4 weeks. Serum metabolic indexes and the curative effect were analyzed after 3 courses of treatment. Results    After treatment, serum levels of cysteine, serine, glycine, N-acetylglutamate, hexadecenoic acid, heptanoic acid in observation group were significantly higher than those in control group; serum levels of cystine, aspartic acid, 3-hydroxybutyric acid and α-linolenic acid level in observation group were significantly lower than those in control group(P＜0.05). The effective rate in observation group was significantly higher than that in control group［33.3%（15/45） vs 25.6%（11/43）］（P=0.035）. The disease control rate showed no significant difference between groups(P=0.054). Incidence rates of grade 0-Ⅰ hypohemia, leucopenia, neutropenia, renal function impairment, nausea and vomitting in observation group were significantly lower than those in control group［35.6%（16/45） vs 55.8%（24/43）, 31.1%（14/45） vs 48.8%（21/43）, 28.9%（13/45） vs 39.5%（17/43）, 6.7%（3/45） vs 14.0%（6/43）, 17.8%（8/45） vs 34.9%（15/43）］(P＜0.05). Incidence rates of thrombopenia and hepatic function impairment showed no significant differences between groups(P＞0.05). Conclusion    Yiqi Fusheng recipe can regulate amino acids and lipid metabolism and reduce adverse reactions in patients with gastric cancer.