设为首页 电子邮箱 联系我们

本刊最新招聘信息请见“通知公告”!  本刊投稿系统试运行中,欢迎投稿!如投稿有问题,可直接将稿件发送至zgyy8888@163.com

 

主管单位:中华人民共和国   

国家卫生健康委员会

主办单位:中国医师协会
总编辑:
杨秋

编辑部主任:吴翔宇

邮发代号:80-528
定价:28.00元
全年:336.00元
Email:zgyy8888@163.com
电话(传真):010-64428528;
010-64456116(总编室)

                  

过刊目录

2018 年第 11 期 第 13 卷

动脉粥样硬化性心血管疾病与H型高血压的关系研究

Relation between atherosclerotic cardiovascular disease and H-type hypertension

作者:张玉马亮亮张海垠    

英文作者:

单位:050051石家庄市第一医院老年病二科(张玉),血管外科(马亮亮);066000河北省秦皇岛市第一医院神经外科(张海垠)

英文单位:

关键词:动脉粥样硬化性心血管疾病;H型高血压;同型半胱氨酸

英文关键词:

  • 摘要:
  • 【摘要】目的    探讨动脉粥样硬化性心血管疾病(ASCVD)与H型高血压的关系。方法    回顾性分析2015年3月至2017年8月于石家庄市第一医院就诊的260例ASCVD患者的病历资料,根据经皮冠状动脉造影检查结果分为观察组(血管狭窄率≥50%,192例)和对照组(血管狭窄率<50%,68例)。统计2组患者基线资料、血脂、血同型半胱氨酸(Hcy)水平及动态血压等检测结果。应用Logistic回归模型分析ASCVD 与H型高血压及患者血Hcy水平的相关性。结果    观察组年龄、H型高血压比例[93.2%(179/192)比45.6%(31/68)]、非杓型或反杓型血压比例[65.6%(126/192)比17.6%(12/68)]、吸烟史比例、糖尿病史比例、三酰甘油水平、血Hcy水平[(24±12)μmol/L比(16±8)μmol/L]大于/高于对照组(均P<0.05)。Logistic回归分析显示,年龄(比值比=1.86,95%置信区间:1.37~2.19,P=0.019 1)、H型高血压(比值比=6.18,95%置信区间:3.45~10.87,P<0.000 1)、非杓型或反杓型血压(比值比=5.68,95%置信区间:4.15~11.08,P=0.001 4)、吸烟史(比值比=4.33,95%置信区间:2.08~9.02,P=0.012 5)、糖尿病史(比值比=2.10,95%置信区间:1.49~3.04,P=0.021 8)、总胆固醇水平(比值比=3.15,95%置信区间:1.88~6.04,P=0.009 7)均为ASCVD发生的危险因素;ASCVD发生风险与血Hcy水平呈明显正相关(r=3.041,P<0.05)。结论    H型高血压患者更易发生ASCVD。H型高血压患者出现非杓型或反杓型血压比例增大,血Hcy水平升高,均为促进ASCVD发生的重要因素,且血Hcy水平越高,发病风险越高。

  • 【Abstract】Objective    To analyze the relation between atherosclerotic cardiovascular disease(ASCVD) and H-type hypertension. Methods    Clinical data of 260 ASCVD patients who were treated in the First Hospital of Shijiazhuang from March 2015 to August 2017 were retrospectively analyzed. According to the results of percutaneous coronary angiography, the patients were divided into observation group(stenosis≥50%, n=192) and control group(stenosis<50%, n=68). Basic medical records, blood lipid, Hcy and ambulatory blood pressure were analyzed. The relation among ASCVD, H-type hypertension and Hcy level was analyzed by Logistic regression. Results    Age, H-type hypertension ratio[93.2%(179/192) vs 45.6%(31/68)], non-dipper and anti-dipper blood pressure ratio[65.6%(126/192) vs 17.6%(12/68)], smoking history ratio, diabetes history ratio, triglyceride level, Hcy level[(24±12)μmol/L vs (16±8)μmol/L] in the observation group were significantly higher than those in the control group(P<0.05). Logistic regression showed that age(odds ratio=1.86, 95% confidence interval: 1.37-2.19, P=0.019 1), H-type hypertension(odds ratio=6.18, 95% confidence interval: 3.45-10.87, P<0.000 1), non-dipper or anti-dipper blood pressure(odds ratio=5.68, 95% confidence interval:4.15-11.08,P=0.001 4), smoking history(odds ratio=4.33, 95% confidence interval: 2.08-9.02, P=0.012 5), diabetes history(odds ratio=2.10, 95% confidence interval: 1.49-3.04, P=0.021 8) and total cholesterol level(odds ratio=3.15, 95% confidence interval: 1.88-6.04, P=0.009 7) were risk factors of ASCVD. There was a positive correlation between ASCVD and Hcy level(r=3.041, P<0.05). Conclusion    sPatients with H-type hypertension are more likely to develop ASCVD. Non-dipper or anti-dipper blood pressure and elevated blood Hcy level in H-type hypertension patients may increase the risk of ASCVD.

copyright 《中国医药》杂志编辑部
地址:北京市朝阳区安贞路2号首都医科大学附属北京安贞医院北楼二层
电话:010-64456116 传真:010-64428528 邮编:100029 Email: zgyy8888@163.com
网址:www.chinamedicinej.com 京ICP备2020043099号-3

当您在使用本网站投稿遇到困难时,请直接将稿件投送到编辑部邮箱zgyy8888@163.com。







安卓


苹果

关闭