设为首页 电子邮箱 联系我们

本刊最新招聘信息请见“通知公告”!  本刊投稿系统试运行中,欢迎投稿!如投稿有问题,可直接将稿件发送至zgyy8888@163.com

 

主管单位:中华人民共和国   

国家卫生健康委员会

主办单位:中国医师协会
总编辑:
杨秋

编辑部主任:吴翔宇

邮发代号:80-528
定价:28.00元
全年:336.00元
Email:zgyy8888@163.com
电话(传真):010-64428528;
010-64456116(总编室)

                  

过刊目录

2019 年第 5 期 第 14 卷

尿酸对非体外循环冠状动脉旁路移植术后心房颤动发生率的影响

Influence of uric acid on incidence of postoperative atrial fibrillation after off-pump coronary artery bypass grafting

作者:吴婷婷王红邵涓涓贾明侯晓彤

英文作者:

单位:100029首都医科大学附属北京安贞医院心外危重症中心

英文单位:

关键词:非体外循环冠状动脉旁路移植术;尿酸;心房颤动;氧化应激

英文关键词:

  • 摘要:
  • 【摘要】目的    探讨术前血尿酸水平升高与非体外循环冠状动脉旁路移植术(OPCABG)患者术后心房颤动发生率的关系。方法    回顾性分析2018年1—6月首都医科大学附属北京安贞医院580例OPCABG术后患者的病历资料,根据术前1 d血尿酸水平分为高尿酸组(102例,男性>420 μmol/L,女性>350 μmol/L)和尿酸正常组(478例)。比较2组术后新发心房颤动的发生率,术后24 h血肌酐水平,术后24 h使用血管活性药物情况,术后左心室射血分数(LVEF),术后置入主动脉内球囊反搏(IABP)、连续性肾脏替代治疗、机械通气时间、住重症监护病房时间、住院时间及转归情况等。结果    高尿酸组与尿酸正常组比较,术后心房颤动发生率明显增加[38.2%(39/102)比24.7%(118/478),P<0.001],术后24 h血肌酐水平明显升高[(102+13)μmol/L比(87+10)μmol/L,P=0.030],术后LVEF明显下降[(42±4)%比(49±5)%,P=0.032],术后置入IABP患者比例明显增加[10.8%(11/102)比6.7%(32/478),P=0.032]。多因素Logistic回归分析提示术后心房颤动(比值比=4.21,95%置信区间:3.87~4.38,P<0.001)、术后24 h血肌酐水平(比值比=2.75,95%置信区间:2.71~2.79,P<0.001)、术后LVEF(比值比=1.57,95%置信区间:1.52~1.61,P=0.030)、术后置入IABP(比值比=1.52,95%置信区间:1.23~1.76,P=0.032)与术前血尿酸水平升高独立相关。结论    术前血尿酸升高是OPCABG患者术后心房颤动发生的独立危险因素及预测因素。

  • 【Abstract】Objective    To investigate the relation between preoperative level of serum uric acid and incidence of postoperative atrial fibrillation in patients with off-pump coronary artery bypass grafting(OPCABG). Methods    A retrospective cohort study was performed on 580 patients who underwent OPCABG in Beijing Anzhen Hospital, Capital Medical University from January to June 2018. According to serum uric acid level 1 d before surgery, the patients were divided into hyperuricemia group(n=102, >420 μmol/L in male and >350 μmol/L in female) and normal group(n=478). Clinical data including the incidence of postoperative new-onset atrial fibrillation, postoperative 24 h serum creatinine and use of vasoactive drugs, left ventricular ejection fraction(LVEF), intra-aortic balloon counterpulsation(IABP), continuous renal replacement therapy, mechanical ventilation time, intensive care unit stay time, hospitalization time and outcomes of patients were analyzed. Results    Compared with normal group, incidence of postoperative atrial fibrillation increased[38.2%(39/102) vs 24.7%(118/478), P<0.001], postoperative 24 h serum creatinine level increased[(102+13)μmol/L vs (87+10)μmol/L, P=0.030], LVEF decreased[(42±4)% vs (49±5)%, P=0.032] and IABP was used more[10.8%(11/102) vs 6.7%(32/478), P=0.032] in hyperuricemia group. Multivariate logistic analysis showed that postoperative atrial fibrillation(odds ratio=4.21, 95% confidence interval: 3.87-4.38, P<0.001), postoperative 24 h serum creatinine(odds ratio=2.75, 95% confidence interval: 2.71-2.79, P<0.001), postoperative LVEF(odds ratio=1.57, 95% confidence interval: 1.52-1.61, P=0.030) and IABP(odds ratio=1.52, 95% confidence interval: 1.23-1.76, P=0.032) were associated with high level of serum uric acid before surgery. Conclusion    Elevated serum uric acid is an independent risk factor and predictor of postoperative new-onset AF in patients undergoing OPCABG.

copyright 《中国医药》杂志编辑部
地址:北京市朝阳区安贞路2号首都医科大学附属北京安贞医院北楼二层
电话:010-64456116 传真:010-64428528 邮编:100029 Email: zgyy8888@163.com
网址:www.chinamedicinej.com 京ICP备2020043099号-3

当您在使用本网站投稿遇到困难时,请直接将稿件投送到编辑部邮箱zgyy8888@163.com。







安卓


苹果

关闭