2019 年第 6 期 第 14 卷

低氧适应防治心脑疾病的研究进展

Prevention and treatment of cardio-cerebral diseases with hypoxic conditioning

作者：喻琬童任长虹吉训明

英文作者：

单位：100053首都医科大学宣武医院神经内科低氧适应转化医学北京市重点实验室

英文单位：

关键词：心脑血管疾病；低氧适应

英文关键词：

• 摘要：

• 【摘要】低氧适应是指在一定时间内1次或多次暴露于短暂、非致死性的低氧环境后，机体的内源性保护机制被激发，从而产生显著的预防及治疗效果，根据其应用的时机，分为预适应和后适应。心脑血管疾病是我国成人第一位致残、致死性疾病，大量研究表明，低氧适应通过对多种信号通路分子的调节，起到对心脏和脑的保护作用。此外，低氧适应对线粒体疾病脑损伤也有保护作用。本文综述了低氧适应对高血压、血脂异常以及糖尿病等心脑血管疾病危险因素的影响。低氧适应安全、无创且易操作，若能实现临床转化，可为缺血缺氧性疾病的防治提供新的选择。

• 【Abstract】Hypoxic conditioning refers to the endogenous protective response of body stimulated by one or more exposures to a transient, non-lethal hypoxic environment, resulting in significant preventive and therapeutic effects. It can be divided into pre-conditioning and post-conditioning. Cardiovascular and cerebrovascular diseases are the first disabling and lethal diseases in adults in China. A large number of studies have shown that hypoxia plays a protective role on heart and brain through various signaling pathways. Hypoxic adaptation has a protective effect on mitochondrial encephalopathy. This paper reviewed the influence of hypoxic conditioning on cardio-cerebrovascular risk factors such as hypertension, hyperlipidemia and diabetes mellitus. As a safe, non-invasive and technically easy method, hypoxic conditioning may provide new options for the prevention and treatment of ischemic and hypoxic diseases.