2020 年第 3 期 第 15 卷

二甲双胍对维吾尔族肥胖型多囊卵巢综合征患者炎症因子水平的影响

Effect of metformin on inflammatory cytokines in Uygur obese patients with polycystic ovary syndrome

作者：古丽阿依木·阿不力孜古丽加那提·马斯开魏巍卢雪玲

英文作者：

单位：新疆医科大学第二附属医院内分泌科，乌鲁木齐830000

英文单位：

关键词：肥胖型多囊卵巢综合征；二甲双胍；维吾尔族；炎症因子

英文关键词：

• 摘要：

• 【摘要】目的    探讨二甲双胍对维吾尔族肥胖型多囊卵巢综合征(PCOS)患血清炎症因子水平的影响。方法    选取2017年4月至2018年5月就诊于新疆医科大学第二附属医院内分泌科的114例肥胖型PCOS患者(体重指数≥25 kg/m2)，其中维吾尔族患者80例，汉族患者34例。2组患者均给予二甲双胍干预12周，对治疗前后血清炎症因子包括肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、IL-1β、C反应蛋白(CRP)水平以及患者自主排卵情况进行比较。结果    治疗前维吾尔族与汉族患者的炎症因子水平差异均无统计学意义（均P＞0.05）。治疗后，汉族患者的TNF-α、IL-6、IL-1β和CRP水平较治疗前明显降低［（6.4±2.3）ng/L比（10.6±3.2）ng/L、（30±6）ng/L比（34±8）ng/L、（25±5）ng/L比（30±8）ng/L、（1.3±0.5）mg/L比（3.5±1.6）mg/L］，差异均有统计学意义（均P＜0.05）；而维吾尔族患者的以上炎症因子水平与治疗前比较差异均无统计学意义（均P＞0.05）。治疗后汉族患者的自主排卵率为61.8%（21/34），维吾尔族患者的自主排卵率为63.8%（51/80），二者之间差异无统计学意义（χ2＝0.086，P＝0.770）。结论    二甲双胍可改善维吾尔族肥胖型PCOS患者的排卵情况，但对患者炎症因子水平无明显影响。

  
  

• 【Abstract】Objective    To observe the effect of metformin on serum inflammatory cytokines in Uygur obese patients with polycystic ovary syndrome(PCOS). Methods    A total of 114 obese patients with PCOS(body mass index≥25 kg/m2), including 80 cases of Uygur patients and 34 cases of Han patients, were enrolled from April 2017 to May 2018 in the Second Affiliated Hospital of Xinjiang Medical University. All patients were treated with metformin for 12 weeks. Inflammatory factors including tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), IL-1β and C-reactive protein(CRP) were detected before and after treatment. Spontaneous ovulation was observed after treatment. Results    There were no significant differences in inflammatory factors between Uygur and Han patients before treatment(all P＞0.05). After treatment, levels of TNF-α, IL-6, IL-1β and CRP significantly decreased in Han patients［（6.4±2.3）ng/L vs （10.6±3.2）ng/L, （30±6）ng/L vs （34±8）ng/L, （25±5）ng/L vs （30±8）ng/L, （1.3±0.5）mg/L vs （3.5±1.6）mg/L］(all P＜0.05), but Uygur patients showed no significant changes（all P＞0.05）. Ovulation rate was 61.8%（21/34） in Han patients and 63.8%（51/80） in Uygur patients, with no statistical difference between them（χ2＝0.086, P＝0.770）. Conclusion    Metformin can improve ovulation in Uygur obese patients with PCOS but shows no obvious effect on inflammatory factors.