2020 年第 4 期 第 15 卷

实施乙型肝炎疫苗免疫后济南地区25岁及以下人群乙型肝炎标志物的检测分析

Detection and analysis of hepatitis B markers in population under 25 years old after hepatitis B vaccine immunization in Jinan

作者：姜健阁1路其凤2沈亚娟2杨西贤2宋培2褚福禄2

英文作者：Jiang Jiangge1 Lu Qifeng2 Shen Yajuan2 Yang Xixian2 Song Pei2 Chu Fulu2

单位：1山东省德州市人民医院检验科253000；2山东大学附属省立医院临床医学检验部，济南250000

英文单位：1Department of Laboratory Dezhou People′s Hospital Shandong Province Dezhou 253000 China; 2Department of Clinical Medicine Laboratory Provincial Hospital Affiliated to Shandong University Jinan 250000 China

关键词：乙型肝炎疫苗；乙型肝炎病毒标志物；计划免疫

英文关键词：HepatitisBvaccine；HepatitisBmarkers；Plannedimmunization

• 摘要：

• 【摘要】目的    了解实施乙型肝炎疫苗（HepB）接种纳入儿童计划免疫管理后济南地区25岁及以下人群的乙型肝炎标志物模式情况。方法    回顾性分析2017年6月至2018年6月在山东大学附属省立医院就诊的25岁及以下患者血清标本6 454份。按照年龄和性别分为0～14岁儿童组共3 494份，其中男儿童组2 071份，女儿童组1 423份；15～25岁青少年组共2 960份，其中男青少年组1 315份，女青少年组1 645份。检测所有患者乙型肝炎病毒五项指标，包括乙型肝炎表面抗原（HBsAg）、乙型肝炎表面抗体（HBsAb）、乙型肝炎e抗原、乙型肝炎e抗体、乙型肝炎核心抗体。结果    0～25岁人群乙型肝炎模式可见19种，其中HBsAb单阳性模式比例最高为58.72%（3 790/6 454），其次为五项全阴性者30.79%（1 987/6 454）。0～25岁HBsAg携带率为3.33%(215/6 454)，其中0～14岁儿童组HBsAg携带率为1.63%（57/3 494），男儿童组HBsAg携带率为1.40%(29/2 071)，女儿童组HBsAg携带率为1.97%(28/1 423)，15～25岁青少年组HBsAg携带率为5.34%（158/2 960），男青少年组HBsAg携带率为6.77%(89/1 315)，女青少年组HBsAg携带率为4.19%(69/1 645)。结论    HepB纳入儿童计划免疫后，有效降低了人群HBsAg携带率。济南地区25岁及以下人群乙型肝炎标志物模式以HBsAb单阳性为主，其次为全阴性者，男女无明显差异。

• 【Abstract】Objective    To investigate the pattern of hepatitis B markers among population under 25 years old in Jinan after the implementation of hepatitis B vaccine in children planned immunization. Methods    A retrospective analysis was conducted on 6 454 serum samples from people under 25 years old who visited Shandong Provincial Hospital Affiliated to Shandong University from June 2017 to June 2018. According to age and sex, they were divided into 0-14 years old(n=3 494) boys(n=2 071) and girls(n=1 423), 15-25 years old(n=2 960) boys(n=1 315) and girls(n=1 645). Hepatitis B surface antigen（HBsAg）, hepatitis B surface antibody（HBsAb）, hepatitis B e-antigen, hepatitis B e-antibody, hepatitis B core antibody were detected. Results    There were 19 modes of hepatitis B markers combination among all subjects. HBsAb single-positive rate was 58.72%(3 790/6 454). Five indicators all-negative rate was 30.79%(1 987/6 454). The carrying rate of HBsAg was 3.33%(215/6 454) in 0-25 years old people. The carrying rate of HBsAg was 1.63%（57/3 494） in 0-14 years old children group, with 1.40%(29/2 071) in boys and 1.97%(28/1 423) in girls; it was 5.34%（158/2 960） in 15-25 years old adolescents group, with 6.77%(89/1 315) in boys and 4.19%(69/1 645) in girls. Conclusions    HBsAg carrying rate is significantly reduced after introducing hepatitis B vaccine into children planned immunization. HBsAb single-positive is the main mode of hepatitis B markers among people aged 25 years and younger in Jinan area; all-negative is also common. There is no obvious difference between males and females.