设为首页 电子邮箱 联系我们

本刊最新招聘信息请见“通知公告”!  本刊投稿系统试运行中,欢迎投稿!如投稿有问题,可直接将稿件发送至zgyy8888@163.com

 

主管单位:中华人民共和国   

国家卫生健康委员会

主办单位:中国医师协会
总编辑:
杨秋

编辑部主任:吴翔宇

邮发代号:80-528
定价:28.00元
全年:336.00元
Email:zgyy8888@163.com
电话(传真):010-64428528;
010-64456116(总编室)

                  

过刊目录

2021 年第 3 期 第 16 卷

血浆Elabela水平对冠心病患者冠状动脉狭窄程度的预测价值

The predictive value of plasma Elabela level for the severity of coronary artery stenosis in patients with coronary atherosclerotic heart disease

作者:冯健张煜李坚王冬雪

英文作者:Feng Jian Zhang Yu Li Jian Wang Dongxue

单位:南京医科大学附属无锡人民医院心血管内科214073

英文单位:

关键词:冠心病(冠状动脉粥样硬化性心脏病);冠状动脉狭窄;Elabela;预测价值

英文关键词:Coronaryatheroscleroticheartdisease;Coronaryarterystenosis;Elabela;Predictivevalue

  • 摘要:
  • 目的 探讨血浆Elabela水平对冠心病(冠状动脉粥样硬化性心脏病)患者冠状动脉狭窄程度的预测价值。方法选取20171月至20201月于南京医科大学附属无锡人民医院接受治疗的冠心病患者80例作为冠心病组,所有冠心病患者均接受冠状动脉造影检查,根据冠状动脉狭窄程度分为重度狭窄组(45例)以及轻度狭窄组(35例)。另选取同期在本院体检的健康志愿者40例作为对照组。收集所有研究对象的一般资料,彩色多普勒超声测量左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF),采用酶联免疫吸附试验法检测血浆N末端B型脑钠肽前体(NT-proBNP)和Elabela水平。采用受试者工作特征(ROC)曲线分析血浆Elabela水平对冠状动脉狭窄程度的预测价值。结果 冠心病组的LVEDDNT-proBNPElabela水平均高于对照组[(53.2±1.2mm比(50.4±1.3mm、(1 036±337ng/L比(129±30ng/L、(4.3±2.1)μg/L比(2.1±1.0)μg/L],LVEF水平低于对照组[(50±9%比(62±5%](均P0.05)。重度狭窄组的LVEDDNT-proBNPElabela水平均高于轻度狭窄组,差异均有统计学意义(均P0.05)。ROC曲线分析显示,冠心病患者血浆Elabela对冠状动脉狭窄程度的预测价值较高,曲线下面积为0.93195%置信区间:0.8740.988),敏感度、特异度和约登指数分别为0.8670.7620.629结论 Elabela在冠心病患者血浆中的表达水平异常升高,且其表达与冠状动脉狭窄程度有一定的相关性,血浆Elabela对冠状动脉狭窄程度的预测价值较高。

  • Objective To investigate the predictive value of plasma Elabela level for the severity of coronary artery stenosis in patients with coronary heart disease(coronary atherosclerotic heart disease). Methods Eighty patients with coronary heart disease admitted to Wuxi Peoples Hospital Affiliated to Nanjing Medical University from January 2017 to January 2020 were selected as the coronary heart disease group. All patients with coronary heart disease received coronary angiography. According to the degree of coronary artery stenosis, they were divided into severe stenosis group(45 cases) and mild stenosis group(35 cases). In addition, 40 healthy volunteers who received physical examination in our hospital during the same period were selected as the control group. The general data of all subjects were collected. Left ventricular end diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF) were measured by color Doppler ultrasound. Enzyme linked immunosorbent assay was used to detect the levels of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) and Elabela. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of plasma Elabela level in the severity of coronary artery stenosis. Results The levels of LVEDD, NT-proBNP and Elabela in the coronary heart disease group were higher than those in the control group[(53.2±1.2mm vs 50.4±1.3mm,1 036±337ng/L vs 129±30ng/L,4.3±2.1)μg/L vs 2.1±1.0)μg/L], and the LVEF level in the coronary heart disease group was lower than that in the control group[(50±9% vs 62±5%(all P0.05). The levels of LVEDD, NT-proBNP and Elabela in severe stenosis group were higher than those in mild stenosis group(all P0.05). ROC curve analysis showed that plasma Elabela had high predictive value for degree of coronary artery stenosis. The area under the curve was 0.931 (95% confidence interval: 0.874-0.988), and the sensitivity, specificity and Youdens index were 0.867, 0.762 and 0.629, respectively. Conclusions The expression level of Elabela in plasma of patients with coronary heart disease is abnormally increased, and its expression has a certain correlation with the degree of coronary artery stenosis. Plasma Elabela has a high predictive value for the degree of coronary artery stenosis.

copyright 《中国医药》杂志编辑部
地址:北京市朝阳区安贞路2号首都医科大学附属北京安贞医院北楼二层
电话:010-64456116 传真:010-64428528 邮编:100029 Email: zgyy8888@163.com
网址:www.chinamedicinej.com 京ICP备2020043099号-3

当您在使用本网站投稿遇到困难时,请直接将稿件投送到编辑部邮箱zgyy8888@163.com。







安卓


苹果

关闭