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2021 年第 5 期 第 16 卷

肺炎支原体RNA与肺炎支原体免疫球蛋白M和免疫球蛋白G水平的关联研究

Association of mycoplasma pneumoniae RNA with mycoplasma pneumoniae immunoglobulin M and immunoglobulin G levels

作者:渠滕鞠瑛刘春梅邱旸张庆崔朝杰刘义庆

英文作者:Qu Teng Ju Ying Liu Chunmei Qiu Yang Zhang Qing Cui Chaojie Liu Yiqing

单位:山东第一医科大学附属省立医院山东省立医院临床检验医学部,济南250021

英文单位:

关键词:肺炎支原体;RNA检测;免疫球蛋白M;免疫球蛋白G

英文关键词:

  • 摘要:
  • 目的 探讨肺炎支原体(MPRNAMP-免疫球蛋白(IgMMP-IgG的相关性。方法 选取201959月就诊于山东第一医科大学附属省立医院的686例疑似呼吸道感染患儿,根据患儿年龄将其分为0~<4岁组(298例)、4~7岁组(276例)和>7岁组(112例)。所有患儿同时检测咽拭子MP-RNA表达及血清MP-IgMMP-IgG水平。比较不同年龄组、性别间MP-RNA阳性率。记录MP-IgMMP-IgG阳性率,MP-RNA MP-IgMMP-IgG的诊断符合率。采用受试者工作特征(ROC)曲线分析MP-IgMMP-IgGMP感染中的诊断价值。结果 686例疑似呼吸道感染患儿中,175例(25.5%MP-RNA阳性,4~7岁组MP-RNA阳性率高于0~3岁组、>7岁组(P<0.05)。男、女MP-RNA阳性率比较差异无统计学意义(P0.05)。体液免疫检测结果显示,MP-IgM阳性MP-IgG阳性组MP-RNA阳性率最高[59.4%114/192)],与其他组合比较差异有统计学意义(χ2=184.29P0.05)。MP-RNAMP-IgM的诊断符合率高于MP-RNAMP-IgG的诊断符合率(P0.05)。对MP感染诊断价值的ROC曲线分析结果显示,MP-IgM曲线下面积为0.858、敏感度为76.00%、特异度为83.37%MP-IgG曲线下面积为0.755、敏感度为54.85%、特异度为88.46%MP-RNA阳性率分别随MP-IgMMP-IgG水平的升高而增高,差异均有统计学意义(均P<0.05)。结论 MP-RNA的阳性率随MP-IgMMP-IgG水平的增高而增高,MP-IgM阳性且MP-IgG阳性患儿MP-RNA阳性率最高。


  • Objective To investigate the correlation of mycoplasma pneumoniae(MP)-RNA with MP-immunoglobulin(Ig) M and MP-IgG. Methods From May to September 2019, 686 children with suspected respiratory infection admitted to Shandong Provincial Hospital Affiliated to Shandong First Medical University were selected. According to the age, they were divided into 0-<4 years group(298 cases), 4-7 years group(276 cases) and >7 years group(112 cases). All children were detected the expression of throat swabs MP-RNA and serum levels of MP-IgM and MP-IgG. MP-RNA positive rates in different age groups and gender were compared. The positive rates of MP-IgM and MP-IgG, and diagnostic concordance rates of MP-RNA with MP-IgM and MP-IgG were recorded. Receiver operating characteristic (ROC) curve was used to analyze the predicting value of MP-IgM and MP-IgG in MP infection. Results Among the 686 cases of suspected respiratory infection, there were 175 cases25.5%) with positive MP-RNA. The positive rate of MP-RNA in 4-7 years group was higher than that in 0-3 years group and >7 years group (P<0.05), but there was no significant difference in positive rate of MP-RNA between male and female (P>0.05). Humoral immunity detection showed that the positive rate of MP-RNA in the positive MP-IgM and positive MP-IgG group was the highest59.4%(114/192)(χ2=184.29 P<0.05). The diagnostic concordance rate of MP-RNA with MP-IgM was higher than that of MP-RNA with MP-IgG (P<0.05). ROC curve analysis in diagnosis of MP infection showed that the area under the curve (AUC) of MP-IgM was 0.858, sensitivity was 76.00% and specificity was 83.37%; the AUC of MP-IgG was 0.755, sensitivity was 54.85% and specificity was 88.46%. The positivity rate of MP-RNA increased with the increasing levels of MP-IgM and MP-IgG, respectively(both P<0.05). Conclusions The positivity rate of MP-RNA increases with the increasing levels of MP-IgM and MP-IgG. Children with positive MP-IgM and positiveMP-IgG have the highest rate of positive MP-RNA.

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