2022 年第 10 期 第 17 卷

兴奋效应与肿瘤的研究进展及机制探讨

Research progress and mechanism of hormesis effect in tumor experiment

作者：李松哲蔡凌云孙阳

英文作者：Li Songzhe Cai Lingyun Sun Yang

单位：黑龙江中医药大学基础医学院，哈尔滨150040

英文单位：School of Basic Medical Sciences Heilongjiang University of Chinese Medicine Harbin 150040 China

关键词：兴奋效应；肿瘤；活性氧；细胞周期

英文关键词：Hormesiseffect;Tumor;Reactiveoxygenspecies;Cellcycle

• 摘要：

• 兴奋效应作为一种低浓度促进、高浓度抑制的毒理学现象，在药学领域逐年受到关注。本文主要从兴奋效应的概念和近年来与之相关的通路靶点、研究进展等角度进行阐述，并基于文献分析了兴奋效应与临床用药潜在风险的相关性。最后，依据近些年的文献对兴奋效应进行讨论，通过缩短细胞间期与加快溶酶体自噬提高有丝分裂速率，表现出增殖现象，而这种短暂的增殖会导致细胞在之后进入有丝分裂的相对低迷期。深入研究兴奋效应将会为抗肿瘤药物在临床的应用奠定基础。

• Hormesis effect is a toxicological phenomenon, which is found in low concentration of drug promotion and high concentration inhibition. It has been attracted more and more attention in the field of pharmacy. In this paper, the concept of hormesis effect, its related pathway targets and research progress are reviewed. The relationship between hormesis effect and potential risk of clinical medication is analyzed based on literature. Finally, according to the literature in recent years, we discussthe hormesis effect is that can increase the mitotic rate by shortening the interphase and acceleratelysosomal autophagy. It showes the phenomenon of proliferation, and leads to a relatively low mitotic phase after this short proliferation. The further study of hormesis effect will lay a foundation for the clinical application of anti-tumor drugs.