2023 年第 1 期 第 18 卷

神经退行性疾病中小胶质细胞糖代谢重编程的研究进展

Research progress of glycolytic reprogramming of microglia in neurodegenerative diseases

作者：苏燕1程晓雷1周艺铭1许敏慧2夏天娇2顾小萍1

英文作者：Su Yan1 Cheng Xiaolei1 Zhou Yiming1 Xu Minhui2 Xia Tianjiao2 Gu Xiaoping1

单位：1南京大学医学院附属鼓楼医院麻醉手术科，南京210000；2南京大学医学院，南京210000

英文单位：1Department of Anesthesiology Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School Nanjing 210000 China; 2Nanjing University Medical School Nanjing 210000 China

关键词：

英文关键词：Neurodegenerativediseases;Glycolyticreprogramming;Microglia

• 摘要：

• 小胶质细胞介导的神经炎症在神经退行性疾病的进展中起重要作用。微环境及压力刺激使小胶质细胞活化为不同表型，参与神经系统的免疫调节和组织稳态的维持。不同状态下小胶质细胞能量代谢谱并不相同。糖代谢是小胶质细胞主要的供能方式，促炎型小胶质细胞通常利用有氧糖酵解方式促进能量的产生，而抗炎型和监视型则主要依赖有氧磷酸化为细胞供能。本文系统总结了小胶质细胞糖代谢重编程在神经退行性疾病中的作用及其可能机制。

• Microglia-mediated neuroinflammation plays an important role in the progression of neurodegenerative diseases. Microenvironment and external stimulations activate microglia into different phenotypes, which are involved in the immune regulation and the homeostasis of the nervous system.In different phenotypes, the metabolism profiles of microglia are not identical. Glucose metabolism is the main energy supply in microglia. Pro-inflammatory microglia chiefly use aerobic glycolysis to promote energy production, while anti-inflammatory and surveillance microglia primarily rely on phosphorylation. This paper reviews the effects and the possible mechanisms of microglia glycolytic reprogramming in neurodegenerative diseases.