2023 年第 9 期 第 18 卷

青鹏软膏联合针刺推拿治疗青藏地区膝骨关节炎患者的临床效果研究

Clinical effect of Qingpeng ointment combined with acupuncture and massage in treating knee osteoarthritis patients in the Qinghai-Tibet region

作者：保善录1赵亮1祁永红2陈鲜霞3高彤1赵秀红1唐纯志4

英文作者：Bao Shanlu1 Zhao Liang1 Qi Yonghong2 Chen Xianxia3 Gao Tong1 Zhao Xiuhong1 Tang Chunzhi4

单位：1青海省人民医院中西医结合科，西宁810000；2青海省人民医院影像科，西宁810000；3青海省人民医院超声科，西宁810000；4广州中医药大学针灸康复临床医学院，广州510006

英文单位：1Department of Integrated Traditional Chinese and Western Medicine Qinghai Provincial People′s Hospital Xining 810000 China; 2Department of Imaging Qinghai Provincial People′s Hospital Xining 810000 China; 3Department of Ultrasound Qinghai Provincial People′s Hospital Xining 810000 China; 4Clinical Medical College of Acupuncture Moxibustion and Rehabilitation Guangzhou University of Chinese Medicine Guangzhou 510006 China

关键词：膝骨关节炎；青鹏软膏；针刺；推拿

英文关键词：Kneeosteoarthritis;Qingpengointment;Acupuncture;Massage

• 摘要：

• 目的 观察青鹏软膏联合针刺推拿治疗青藏地区膝骨关节炎（KOA）患者的临床效果。方法 选取2021年3月至2022年3月青海省人民医院门诊收治的KOA患者80例，按照随机数字表法分为对照组和观察组，各40例。对照组给予口服硫酸氨基葡萄糖片；观察组给予青鹏软膏联合针刺推拿治疗。比较2组患者治疗前、治疗后、停止治疗3个月后血清炎症因子白细胞介素1β（IL-1β）、IL-6、肿瘤坏死因子α（TNF-α）水平，患侧膝关节视觉模拟量表（VAS）疼痛评分、Lysholm膝关节功能评分、患膝关节被动屈曲度（PROM）。比较2组患者临床疗效。结果 治疗后，观察组IL-6水平低于对照组，差异有统计学意义（P＜0.05）。停止治疗3个月后，观察组IL-1β、IL-6、TNF-α水平均低于对照组，差异均有统计学意义（均P＜0.05）。治疗后及停止治疗3个月后观察组患侧膝关节VAS疼痛评分低于对照组、Lysholm膝关节功能评分高于对照组，患膝关节PROM大于对照组（均P＜0.05）。治疗后，2组总有效率比较差异无统计学意义（P＞0.05）。停止治疗3个月后，观察组总有效率明显高于对照组［95.0%（38/40）比52.5%（21/40）］（P＜0.05）。结论 青鹏软膏联合针刺推拿治疗KOA短期疗效明显，长期疗效维持较好，能有效缓解患者膝关节痛和活动功能障碍。

• Objective To observe the clinical effect of Qingpeng ointment combined with acupuncture and massage in treating knee osteoarthritis (KOA) patients in the Qinghai-Tibet region. Methods From March 2021 to March 2022, 80 patients with KOA admitted to the outpatient clinic of Qinghai Provincial People′s Hospital were selected. They were divided into control and observation groups according to the random number table method, with 40 cases in each group. The control group was given oral glucosamine sulfate tablets, and the observation group was given Qingpeng ointment combined with acupuncture and massage treatment. The levels of serum inflammatory factor interleukin-1β（IL-1β）, IL-6, tumour necrosis factor α（TNF-α）, visual analog scale (VAS) pain score of the affected knee joint, Lysholm knee function score, and degree of passive flexion (PROM) of the affected knee joint were compared between the two groups before treatment, after treatment, and 3 months after cessation of treatment. Clinical efficacies were compared between the two groups. Results After treatment, the level of IL-6 in the observation group was lower than that in the control group (P＜0.05). Three months after cessation of treatment, the levels of IL-1β, IL-6, TNF-α in the observation group were lower than those in the control group (all P＜0.05). After treatment and 3 months after cessation of treatment, VAS pain score of the affected knee joint in the observation group was lower than that in the control group, Lysholm knee function score was higher than that in the control group, and PROM of the affected knee joint was greater than that in the control group (all P＜0.05). After treatment, there was no statistically significant difference in the total effective rate between the two groups (P＞0.05). Three months after cessation of treatment, the total effective rate in the observation group was significantly higher than that in the control group ［95.0%(38/40) vs 52.5%(21/40)］(P＜0.05). Conclusions  Qingpeng ointment combined with acupuncture and massage in treating KOA has obvious short-term efficacy, the long-term efficacy is maintained relatively well, and it can effectively relieve knee joint pain and activity dysfunction.