2026 年第 2 期 第 21 卷

潞党参口服液联合隔姜灸治疗晚期非小细胞肺癌化疗后免疫功能低下的临床效果观察

Clinical efficacy observation of Ludangshen oral liquid combined with ginger-separated moxibustion in treating immune hypofunction in patients with advanced non-small cell lung cancer after chemotherapy

作者：江正龙常金圆冯利

英文作者：Jiang Zhenglong Chang Jinyuan Feng Li

单位：国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院中医科，北京100021

英文单位：Department of Traditional Chinese Medicine Cancer Hospital Peking Union Medical College Chinese Academy of Medical Sciences National Clinical Research Center for Cancer National Cancer Center Beijing 100021 China

关键词：晚期非小细胞肺癌；潞党参口服液；隔姜灸；免疫功能

英文关键词：Advancednon-smallcelllungcancer;Ludangshenoralliquid;Ginger-separatedmoxibustion;Immunefunction

• 摘要：

• 目的 探讨潞党参口服液联合隔姜灸治疗晚期非小细胞肺癌（NSCLC）化疗后免疫功能低下的临床效果。方法 选择2024年2月至2025年2月于中国医学科学院肿瘤医院接受治疗的晚期NSCLC化疗后免疫功能低下患者120例作为研究对象。采用信封法随机分为对照组和观察组，各60例。对照组在对症与支持治疗基础上采用隔姜灸治疗；观察组在对照组基础上联合潞党参口服液治疗，2组患者均连续治疗1个月。比较2组患者的临床疗效、治疗前后Piper疲乏量表和Karnofsky功能状态（KPS）评分、免疫功能指标、中医证候评分和不良反应发生率。结果观察组患者总有效率明显高于对照组［85.0%（51/60）比76.7%（46/60）］（P=0.027）。治疗后观察组和对照组患者的Piper疲乏量表评分、CD+8比例、中医证候主症、次症及总评分均显著低于治疗前且观察组均低于对照组，而KPS评分、CD+3、CD+4、自然杀伤细胞比例及CD+4/CD+8比值均显著高于治疗前且观察组均高于对照组（均P<0.05）。观察组和对照组不良反应总发生率比较差异无统计学意义［36.7%（22/60）比48.3%（29/60）］（P=0.196）。结论 潞党参口服液联合隔姜灸能够有效提高晚期NSCLC化疗后免疫功能低下患者的治疗效果，同时缓解癌因性疲乏，改善生活质量，另外能够有效提高免疫功能，临床安全性较高。

• Objective To investigate the clinical efficacy of Ludangshen oral liquid combined with ginger-separated moxibustion in treating immune hypofunction in patients with advanced non-small cell lung cancer (NSCLC) after chemotherapy. Methods A total of 120 patients with immune hypofunction after chemotherapy for advanced NSCLC who were treated in Cancer Hospital, Chinese Academy of Medical Sciences from February 2024 to February 2025 were enrolled as research subjects. They were randomly divided into the control group and the observation group using the envelope method, with 60 cases in each group. The control group was treated with ginger-separated moxibustion on the basis of symptomatic and supportive treatment, while the observation group was treated with Ludangshen oral liquid combined with the regimen of the control group. Both groups were treated continuously for 1 month. The clinical efficacy, Piper fatigue scale scores, Karnofsky performance status (KPS) scores, immune function indexes, traditional Chinese medicine (TCM) syndrome scores and incidence of adverse reactions were compared between the two groups before and after treatment. Results The total effective rate of the observation group was significantly higher than that of the control group ［85.0%(51/60) vs 76.7%(46/60)］(P=0.027). After treatment, the Piper fatigue scale scores, CD+8 ratio, scores of TCM syndrome primary symptoms, secondary symptoms and total scores in both the observation group and the control group were significantly lower than those before treatment, and the indexes in the observation group were significantly lower than those in the control group; while the KPS scores, CD+3, CD+4, natural killer cell ratio and CD+4/CD+8 ratio were significantly higher than those before treatment, and the indexes in the observation group were significantly higher than those in the control group (all P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the observation group and the control group ［36.7%(22/60) vs 48.3%(29/60)］(P=0.196). Conclusion Ludangshen oral liquid combined with ginger-separated moxibustion can effectively improve the therapeutic effect in patients with immune hypofunction after chemotherapy for advanced NSCLC, relieve cancer-related fatigue, improve quality of life, enhance immune function, and has high clinical safety.