2026 年第 2 期 第 21 卷

肥胖与炎症性肠病关系的研究进展

Research progress on the relationship between obesity and inflammatory bowel disease

作者：周波1吴大伟1王祥2

英文作者：Zhou Bo1 Wu Dawei1 Wang Xiang2

单位：1兰州大学第二临床医学院，兰州730030；2兰州大学第二医院消化科，兰州730030

英文单位：1The Second Clinical Medical School Lanzhou University Lanzhou 730030 China; 2Department of Gastroenterology The Second Hospital Lanzhou University Lanzhou 730030 China

关键词：炎症性肠病；溃疡性结肠炎；克罗恩病；肥胖

英文关键词：Inflammatoryboweldisease;Ulcerativecolitis;Crohn′sdisease;Obesity

• 摘要：

• 现代生活方式中缺乏身体活动和饮食结构的改变导致肥胖的患病率呈上升趋势。肥胖作为慢性疾病中的独立病种及多种慢性疾病的致病因素，目前已经成为我国重大公共卫生问题。炎症性肠病是一种慢性非特异性肠道炎症性疾病，其患病率呈上升趋势，与肥胖的患病率变化相平行。因此，本文就肥胖与炎症性肠病关系的研究进展进行综述，以期更好地了解肥胖在炎症性肠病发生发展中的作用，为临床诊疗提供理论依据。

• In modern lifestyles, physical inactivity and changes in dietary structure have led to an increasing prevalence of obesity. As an independent chronic disease and a pathogenic factor for various chronic conditions, obesity has become a major public health issue in China. Inflammatory bowel disease (IBD) is a chronic nonspecific inflammatory intestinal disorder with a rising prevalence, which parallels the epidemiological trend of obesity. Therefore, this review summarizes the research progress on the relationship between obesity and IBD, aiming to better understand the role of obesity in the pathogenesis and progression of IBD and provide a theoretical basis for clinical diagnosis and treatment.