2026 年第 2 期 第 21 卷

翻转式成蛋白2在人类恶性肿瘤中的研究进展

Research progress on inverted formin 2 in human malignant tumors

作者：刘常乐1肖瑞2王乃赓1任建军1

英文作者：Liu Changle1 Xiao Rui2 Wang Naigeng1 Ren Jianjun1

单位：1内蒙古医科大学附属医院肝胆外科，呼和浩特010050；2内蒙古医科大学分子病理学重点实验室，呼和浩特010050

英文单位：1Department of Hepatobiliary Surgery the Affiliated Hospital of Inner Mongolia Medical University Hohhot 010050 China; 2Key Laboratory of Molecular Pathology Inner Mongolia Medical University Hohhot 010050 China

关键词：恶性肿瘤；翻转式成蛋白2；线粒体动力学；细胞骨架；治疗靶点

英文关键词：Malignanttumors;Invertedformin2;Mitochondrialdynamics;Cytoskeleton;Therapeutictarget

• 摘要：

• 翻转式成蛋白2（INF2）作为成蛋白家族中兼具肌动蛋白聚合与解聚双重功能的成员，近年来在肿瘤发生发展中的作用日益受到关注。INF2通过调控线粒体动力学、细胞骨架重构、细胞器互作等过程，在多种恶性肿瘤中发挥复杂的作用。本文综述了INF2在不同类型肿瘤中的功能机制及其潜在的临床应用价值，同时探讨了INF2作为潜在治疗靶点的研究现状及未来发展方向，以期为临床治疗提供新的思路和策略。

• Inverted formin 2 (INF2), a member of the formin family with dual functions of actin polymerization and depolymerization, has attracted increasing attention in tumorigenesis and development in recent years. By regulating mitochondrial dynamics, cytoskeleton remodeling, organelle interaction and other processes, INF2 exerts complex roles in various malignant tumors. This paper reviews the functional mechanisms of INF2 in different types of tumors and its potential clinical application value, and also discusses the research status and future development direction of INF2 as a potential therapeutic target, aiming to provide new ideas and strategies for clinical treatment.