2026 年第 4 期 第 21 卷

C反应蛋白-甘油三酯-葡萄糖指数与中老年高血压风险的关系研究

Study on the relationship between C-reactive protein-triglyceride-glucose index and risk of hypertension in middle-aged and elderly individuals

作者：刘艺轩王可馨王文杰牛佳龙王忠可刘晓丽王志坚韩红亚葛海龙

英文作者：Liu Yixuan Wang Kexin Wang Wenjie Niu Jialong Wang Zhongke Liu Xiaoli Wang Zhijian Han Hongya Ge Hailong

单位：首都医科大学附属北京安贞医院心血管内科，北京100029

英文单位：Department of Cardiovascular Medicine Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

关键词：高血压病；C反应蛋白-甘油三酯-葡萄糖指数；中老年人；中国健康与养老追踪调查

英文关键词：Hypertension;C-reactiveprotein-triglyceride-glucoseindex;Middle-agedandelderlyindividuals;Chinahealthandretirementlongitudinalstudy

• 摘要：

• 目的 基于中国健康与养老追踪调查（CHARLS）数据探讨C反应蛋白-甘油三酯-葡萄糖指数（CTI）与高血压的关系。方法 选取CHARLS数据库2011—2015年记录的年龄≥45岁人群。采用Cox回归分析CTI连续变量及CTI分组与高血压发病风险的关系。绘制限制性立方样条（RCS）分析CTI与高血压风险的剂量-反应关系。根据年龄(是否≥60岁)、性别、居住地、吸烟、饮酒进行亚组分析。结果 共纳入5 210例研究对象，其中1 579例新发高血压病（高血压组），其余3 631例纳入非高血压组。与非高血压组相比，高血压组人群年龄更大，男性占比更高，已婚者占比更低，吸烟者、饮酒者所占比例均更高，心脏病、糖尿病、脑卒中、血脂异常、肺病的患病率更高，低密度脂蛋白胆固醇、体重指数、CTI的数值更大(均P＜0.05)。以CTI三分位数为界设立3组：T1（5.99≤CTI≤8.27）、T2（8.27＜CTI≤8.96）和T3（8.96＜CTI≤12.79）。在模型3中，CTI与新发高血压风险显著相关（风险比=1.16，95%置信区间：1.08~1.25，P＜0.001）；以T1为参照，T2、T3均与新发高血压风险显著增加密切相关（T2：风险比=1.20，95%置信区间：1.04~1.38，P=0.015；T3：风险比=1.35，95%置信区间：1.17~1.57，P＜0.001）。趋势检验提示高血压发病风险与CTI分组增加显著相关(P趋势＜0.001)。RCS分析结果显示CTI与中国中老年人高血压病发生风险呈线性关系（P整体＜0.001，P非线性=0.254）。亚组分析显示CTI与高血压发病风险的正相关关联在男性以及农村居民中显著，且不受年龄、吸烟状态或饮酒状态的影响。结论 CTI增大是中老年人发生高血压风险的危险因素。

• Objective To investigate the association between C-reactive protein-triglyceride-glucose index (CTI) and hypertension based on data from the China health and retirement longitudinal study (CHARLS). Methods Participants aged ≥45 years recorded in the CHARLS database from 2011 to 2015 were enrolled. Cox regression was used to analyze the relationships of continuous CTI and CTI subgroups with the risk of incident hypertension. Restricted cubic spline (RCS) analysis was performed to explore the dose-response relationship between CTI and hypertension risk. Subgroup analyses were conducted according to age (≥60 years or not), gender, residence, smoking, and drinking status. Results A total of 5 210 participants were included, among whom 1 579 developed incident hypertension (hypertension group) and the remaining 3 631 were included in the non-hypertension group. Compared with the non-hypertension group, participants in the hypertension group were older, had a higher proportion of males, a lower proportion of married individuals, higher percentages of smokers and drinkers, higher prevalence rates of heart disease, diabetes, stroke, dyslipidemia, and lung disease, as well as higher levels of low-density lipoprotein cholesterol, body mass index, and CTI (all P<0.05). Participants were divided into three groups by tertiles of CTI: T1(5.99≤CTI≤8.27), T2(8.27＜CTI≤8.96), and T3(8.96＜CTI≤12.79). In model 3, CTI was significantly associated with an increased risk of incident hypertension (hazard ratio=1.16, 95% confidence interval: 1.08-1.25, P<0.001). Compared with T1, both T2 and T3 were significantly related to an increased risk of incident hypertension (T2: hazard ratio=1.20, 95% confidence interval: 1.04-1.38, P=0.015; T3: hazard ratio=1.35, 95% confidence interval: 1.17-1.57, P<0.001). Trend test indicated that the risk of incident hypertension was significantly associated with elevated CTI subgroups (Pfor trend<0.001). RCS analysis showed a linear relationship between CTI and the risk of hypertension in middle-aged and elderly Chinese individuals (Poverall<0.001, Pnonlinear=0.254). Subgroup analyses revealed that the positive association between CTI and hypertension risk was significant in males and rural residents, and was not affected by age, smoking, or drinking status. Conclusion CTI increase is a risk factor for hypertension in middle-aged and elderly individuals.