2026 年第 5 期 第 21 卷

经皮穴位电刺激联合肠外营养对腹腔镜下胃癌根治术后患者胃肠功能及血清胃动素和生长抑素水平的影响

Effects of transcutaneous acupoint electrical stimulation combined with parenteral nutrition on gastrointestinal function and serum motilin and somatostatin levels in patients after laparoscopic radical gastrectomy for gastric cancer

作者：王克邪李峰杨孙虎

英文作者：Wang Kexie Li Feng Yang Sunhu

单位：上海市中西医结合医院普外科，上海200082

英文单位：Department of General Surgery Shanghai Hospital of Integrated Traditional Chinese and Western Medicine Shanghai 200082 China

关键词：腹腔镜下胃癌根治术；肠外营养；经皮穴位电刺激；胃肠功能；胃动素；生长抑素

英文关键词：Laparoscopicradicalgastrectomyforgastriccancer;Parenteralnutrition;Transcutaneousacupointelectricalstimulation;Gastrointestinalfunction;Motilin;Somatostatin

• 摘要：

• 目的 探究经皮穴位电刺激（TAES）联合肠外营养对腹腔镜胃癌根治术（LRG）后患者胃肠功能及血清胃动素和生长抑素水平的影响。方法 选取2023年1月至2024年12月于上海市中西医结合医院进行LRG的90例患者。采用随机数字表法分为肠外营养组和联合组，各45例。肠外营养组在常规治疗基础上术后第1天开始采用脂肪乳氨基酸（17）葡萄糖（11%）注射液中心静脉滴注；联合组在肠外营养组基础上加用经皮穴位电刺激治疗，2组均治疗1周。比较2组胃肠功能、血清学指标、免疫功能指标和不良反应发生情况。结果 联合组肠鸣音恢复时间、肛门排气时间、排便时间均明显短于肠外营养组（均P＜0.05）。治疗后2组胃动素水平均高于治疗前且联合组高于肠外营养组，生长抑素水平均低于治疗前且联合组低于肠外营养组［组间：（256±29）ng/L比（231±25）ng/L、（16.9±1.5）ng/L比（18.7±1.9）ng/L］（均P＜0.05）。治疗后2组CD+4水平及CD+4/CD+8比值均高于治疗前且联合组高于肠外营养组，CD+8水平均低于治疗前且联合组低于肠外营养组（均P＜0.05）。联合组不良反应发生率低于肠外营养组［6.7%（3/45）比24.4%（11/45）］（P=0.042）。结论 TAES联合肠外营养能够有效促进LRG患者术后胃肠功能改善，改善血清胃动素、生长抑素水平，优化机体免疫功能，减少不良反应发生。

• Objective To investigate the effects of transcutaneous acupoint electrical stimulation (TAES) combined with parenteral nutrition on gastrointestinal function and serum motilin and somatostatin levels in patients after laparoscopic radical gastrectomy (LRG) for gastric cancer. Methods A total of 90 patients who underwent LRG at Shanghai Hospital of Integrated Traditional Chinese and Western Medicine from January 2023 to December 2024 were selected and divided into the parenteral nutrition group and the combined group with 45 cases in each group using a random number table method. On the basis of conventional treatment, the parenteral nutrition group received central venous infusion of fat emulsion, amino acids (17) and glucose (11%) injection starting on the first day after surgery; the combined group was additionally treated with TAES on the basis of the parenteral nutrition group. Both groups were treated for 1 week. Gastrointestinal function, serological indicators, immune function indicators and the incidence of adverse reactions were compared between the two groups. Results The recovery time of bowel sounds, anal exhaust time and defecation time in the combined group were significantly shorter than those in the parenteral nutrition group (all P＜0.05). After treatment, the serum motilin levels in both groups were higher than those before treatment, and the level in the combined group was higher than that in the parenteral nutrition group; the serum somatostatin levels in both groups were lower than those before treatment, and the level in the combined group was lower than that in the parenteral nutrition group ［between groups: (256±29)ng/L vs (231±25)ng/L, (16.9±1.5)ng/L vs (18.7±1.9)ng/L］(all P＜0.05). After treatment, the CD+4 level and CD+4/CD+8 ratio in both groups were higher than those before treatment, and the indices in the combined group were higher than those in the parenteral nutrition group; the CD+8 level in both groups was lower than that before treatment, and the level in the combined group was lower than that in the parenteral nutrition group (all P＜0.05). The incidence of adverse reactions in the combined group was lower than that in the parenteral nutrition group ［6.7%(3/45) vs 24.4%(11/45)］(P=0.042). Conclusions TAES combined with parenteral nutrition can effectively promote the recovery of postoperative gastrointestinal function, improve serum motilin and somatostatin levels, optimize the body′s immune function and reduce the occurrence of adverse reactions in patients after LRG.