2026 年第 5 期 第 21 卷

脉冲电场导管消融植物模型研究进展

Research progress on plant models of pulsed electric field catheter ablation

作者：李伊旋尹洁雯邵文宇蒋晨曦

英文作者：Li Yixuan Yin Jiewen Shao Wenyu Jiang Chenxi

单位：首都医科大学附属北京安贞医院心律失常中心二病区，北京100029

英文单位：Second Ward Arrhythmia Center Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

关键词：脉冲电场；导管消融；不可逆电穿孔；植物模型

英文关键词：Pulsedelectricfield;Catheterablation;Irreversibleelectroporation;Plantmodels

• 摘要：

• 脉冲电场消融（PFA）是一种基于不可逆电穿孔效应的非热能导管消融技术，凭借其独特的组织选择性与安全性，已成为心律失常治疗领域的研究热点。该技术通过高频电脉冲使心肌细胞膜发生不可逆穿孔，利用心肌细胞与其他组织（如血管、神经、食管）对脉冲电场耐受阈值的差异，实现心肌靶点消融并避免邻近组织损伤。系统梳理PFA植物模型研究进展，对阐明PFA的生物物理机制、优化脉冲参数、消融策略及避免潜在并发症至关重要。本文将对PFA植物模型研究进展进行综述，旨在为该技术的临床转化与应用拓展提供理论依据。

• Pulsed field ablation (PFA) is a non-thermal catheter ablation technique based on irreversible electroporation. With its unique tissue selectivity and safety, PFA has become a research hotspot in the field of arrhythmia treatment. This technology induces irreversible perforation of myocardial cell membranes through high-frequency electric pulses, and achieves targeted myocardial ablation while avoiding damage to adjacent tissues by utilizing the difference in tolerance thresholds to pulsed electric fields between myocardial cells and other tissues (such as blood vessels, nerves, and esophagus). Systematically summarizing the research progress of PFA plant models is crucial for clarifying the biophysical mechanism of PFA, optimizing pulse parameters and ablation strategies, and preventing potential complications. This article reviews the research progress of PFA plant models, aiming to provide a theoretical basis for the clinical translation and application expansion of this technology.