2025 年第 12 期 第 20 卷

银黄清肺胶囊联合盐酸氨溴索雾化吸入治疗慢性支气管炎急性发作的效果及安全性研究

Study on the effect and safety of Yinhuang Qingfei capsules combined with ambroxol hydrochloride aerosol inhalation in the treatment of acute attack of chronic bronchitis

作者：胡生瑞张鹏飞冯传杰

英文作者：Hu Shengrui Zhang Pengfei Feng Chuanjie

单位：延安大学附属医院急诊内科，延安716000

英文单位：Department of Emergency Medicine Yan′an University Affiliated Hospital Yan′an 716000 China

关键词：慢性支气管炎；急性发作期；银黄清肺胶囊；盐酸氨溴索；血气分析；炎症

英文关键词：Chronicbronchitis;Acuteattackstage;YinhuangQingfeicapsules;Ambroxolhydrochloride; Bloodgasanalysis;Inflammation

• 摘要：

• 目的 探讨银黄清肺胶囊联合盐酸氨溴索雾化吸入治疗慢性支气管炎急性发作的临床效果及安全性。方法 选取2022年6月至2024年11月在延安大学附属医院接受治疗的96例慢性支气管炎急性发作患者，依据随机数字表法分为对照组与观察组，各48例。对照组患者在抗菌药物基础上雾化吸入盐酸氨溴索治疗，2～3 ml/次，1～2次/d。观察组在对照组基础上加用银黄清肺胶囊进行治疗，3粒/次，3次/d口服。2组患者均接受连续7 d的治疗。比较2组临床总有效率，临床症状改善时间、治疗前后血气分析指标、血清炎症因子水平以及不良反应发生率。结果 观察组临床总有效率显著高于对照组［95.8%（46/48）比81.2%（39/48）］（P=0.025）。治疗后，观察组患者咳嗽、咳痰、喘息及哮鸣音缓解时间均明显短于对照组（均P＜0.05）。治疗后，2组患者动脉血氧分压（PaO2）和动脉血氧饱和度（SaO2）水平均明显高于治疗前，而动脉血二氧化碳分压（PaCO2）均显著低于治疗前，同时观察组患者治疗后PaO2和SaO2水平均明显高于对照组，而PaCO2显著低于对照组（均P＜0.05）。治疗后，2组患者血清TNF-α、IL-6、IL-8和CRP水平均明显低于治疗前，且观察组患者治疗后血清炎症因子水平均显著低于对照组（均P＜0.05）。对照组和观察组不良反应发生率比较［8.3%(4/48)比4.2%(2/48)］，差异无统计学意义（P=0.672）。结论 银黄清肺胶囊与盐酸氨溴索雾化吸入联合应用在治疗慢性支气管炎急性发作上展现出显著的临床效果，可改善临床症状和血气分析指标，抑制炎症反应，且用药安全性高。

• Objective To investigate the clinical effect and safety of Yinhuang Qingfei capsules combined with ambroxol hydrochloride aerosol inhalation in the treatment of acute attack of chronic bronchitis. Methods A total of 96 patients with acute attack of chronic bronchitis treated in Yan′an University Affiliated Hospital from June 2022 to November 2024 were selected, and they were divided into control group and observation group according to the random number table method, with 48 cases in each group. Patients in the control group were treated with aerosol inhalation of ambroxol hydrochloride on the basis of antimicrobial agent, 2-3 ml/time, 1-2 times/d. The observation group was treated with Yinhuang Qingfei capsules oral on the basis of the control group, 3 capsules/time, 3 times/d. Both groups were treated continuously for 7 d. The total clinical effective rate, the improvement time of clinical symptoms, blood gas analysis indexes before and after treatment, serum inflammatory factor levels, and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of the observation group was significantly higher than that of the control group ［95.8%(46/48) vs 81.2%(39/48)］(P=0.025). After treatment, the relief times of cough, expectoration, wheezing and wheezing sound in the observation group were significantly shorter than those in the control group (all P＜0.05). After treatment, the levels of arterial partial pressure of oxygen (PaO2) and arterial oxygen saturation (SaO2) in the two groups were significantly higher than those before treatment, while the levels of arterial partial pressure of carbon dioxide (PaCO2) were significantly lower than those before treatment; at the same time, the levels of PaO2 and SaO2 in the observation group were significantly higher than those in the control group, while PaCO2 was significantly lower than that in the control group (all P＜0.05). After treatment, the serum levels of tumor necrosis factor-α, interleukin-6, interleukin-8 and C-reactive protein in the two groups were significantly lower than those before treatment, and the serum levels of inflammatory factors in the observation group were significantly lower than those in the control group after treatment (all P＜0.05). There was no significant difference in the incidence of adverse reactions between the control group and the observation group ［8.3%(4/48) vs 4.2%(2/48)］(P=0.672). Conclusion Yinhuang Qingfei capsules combined with ambroxol hydrochloride aerosol inhalation in the treatment of acute attack of chronic bronchitis shows significant clinical effect, can improve clinical symptoms and blood gas analysis indicators, inhibit inflammatory response, and has high drug safety.