2025 年第 12 期 第 20 卷

血肌酐与胱抑素C比值在冠心病中的研究进展

Research progress of serum creatinine to cystatin C ratio in coronary atherosclerotic heart disease

作者：陈文馨1王福华2甄帅兴1牛志凤2张莎莎2

英文作者：Chen Wenxin1 Wang Fuhua2 Zhen Shuaixing1 Niu Zhifeng2 Zhang Shasha2

单位：1承德医学院研究生学院，承德067000；2河北省承德市中心医院心血管内科二病区，承德067000

英文单位：1The Graduate School Chengde Medical College Chengde 067000 China; 2Ward Ⅱ of Department of Cardiovascular Medicine Chengde Central Hospital Hebei Province Chengde 067000 China

关键词：冠心病（冠状动脉粥样硬化性心脏病）；血肌酐与胱抑素C比值；肾功能标志物；肌肉质量标志物；早期诊断

英文关键词：Coronaryatheroscleroticheartdisease;SerumcreatininetocystatinCratio;Renalfunctionmarkers;Musclemassmarkers;Earlydiagnosis

• 摘要：

• 冠心病(冠状动脉粥样硬化性心脏病)是威胁人类健康的主要疾病之一。肾功能下降与冠心病的发生、发展存在着相互促进的关系。血肌酐与胱抑素C比值(CCR)作为评价肾功能的新型标志物，相较于单一指标优势明显，近些年CCR在冠心病的研究中亦备受关注。国内外研究发现CCR降低与冠心病发生风险及冠状动脉病变严重程度、不良心血管事件发生风险、冠状动脉重建术中术后不良事件发生风险、主动脉硬化症存在相关性，因此可以作为冠心病的早期诊断、病情评估和预后判断的有效指标。本文归纳总结了CCR与冠心病发生及病情发展的关系，并综述了其在冠心病中的研究进展，以期为冠心病的诊疗提供新的方向。

• Coronary atherosclerotic heart disease is one of the major diseases threatening human health. There is a mutual promoting relationship between the decline of renal function and the occurrence and development of coronary atherosclerotic heart disease. The ratio of serum creatinine to cystatin C (CCR) is a new marker for evaluating renal function. Compared with a single index, CCR has obvious advantages. In recent years, CCR has also attracted much attention in the study of coronary atherosclerotic heart disease. Domestic and foreign studies have found that the reduction of CCR is related to the risk of coronary atherosclerotic heart disease and the severity of coronary artery disease, the risk of adverse cardiovascular events, the risk of adverse events during and after coronary artery reconstruction, and aortic sclerosis. Therefore, it can be used as an effective index for the early diagnosis, condition evaluation and prognosis of coronary atherosclerotic heart disease. This article summarizes the relationship between CCR and the occurrence and development of coronary atherosclerotic heart disease, and reviews its research progress in coronary atherosclerotic heart disease, in order to provide a new direction for the diagnosis and treatment of coronary atherosclerotic heart disease.