2026 年第 7 期 第 21 卷

小窝蛋白1在糖尿病周围神经病变中的研究进展

Research progress of caveolin-1 in diabetic peripheral neuropathy

作者：田刚1李飞霞2袁涛1苏鑫安3

英文作者：Tian Gang1 Li Feixia2 Yuan Tao1 Su Xin′an3

单位：1兰州大学第一医院疼痛科，兰州730030；2甘肃省肿瘤医院妇瘤二科，兰州730050；3兰州大学第一医院风湿病科，兰州730030

英文单位：1Department of Painology The First Hospital of Lanzhou University Lanzhou 730030 China; 2Second Department of Gynecological Oncology Gansu Provincial Cancer Hospital Lanzhou 730050 China; 3Department of Rheumatology The First Hospital of Lanzhou University Lanzhou 730030 China

关键词：糖尿病周围神经病变；小窝蛋白1；神经保护；炎症反应；信号传导

英文关键词：Diabeticperipheralneuropathy;Caveolin-1;Neuroprotection;Inflammatoryresponse; Signaltransduction

• 摘要：

• 糖尿病周围神经病变（DPN）是糖尿病患者中最常见且严重的并发症，显著影响患者的生活质量和预后。DPN涉及代谢紊乱、氧化应激、炎症反应及神经损伤，其分子机制仍未完全明确。小窝蛋白1是细胞膜小窝的关键结构蛋白，广泛参与细胞信号传导、膜结构调节及代谢过程。研究发现，小窝蛋白1在神经保护、炎症调控及代谢平衡中发挥重要作用，其表达和功能异常与DPN的发生发展密切相关。本文系统综述了小窝蛋白1在DPN中的作用机制及其调控信号通路，分析其作为潜在治疗靶点的价值和研究进展，以期为DPN的机制探讨及临床干预提供新的理论依据和策略支持。

• Diabetic peripheral neuropathy (DPN) is one of the most common and severe complications in diabetic patients, which significantly affects patients′ quality of life and prognosis. The pathogenesis of DPN involves metabolic disorder, oxidative stress, inflammatory response and nerve injury, and its molecular mechanism remains not fully clarified. Caveolin-1 is a key structural protein of cell membrane caveolae, which is widely involved in cell signal transduction, membrane structure regulation and metabolic processes. Accumulating studies have demonstrated that caveolin-1 plays an important role in neuroprotection, inflammatory regulation and metabolic homeostasis, and its abnormal expression and function are closely associated with the occurrence and progression of DPN. This article systematically reviews the mechanism and regulatory signaling pathways of caveolin-1 in DPN, and analyzes its research progress and value as a potential therapeutic target, aiming to provide new theoretical basis and strategic reference for mechanism exploration and clinical intervention of DPN.