2026 年第 10 期 第 21 卷

对抗反转录病毒治疗耐药人类免疫缺陷病毒感染/获得性免疫缺陷综合征患者合并抑郁症现状及相关因素研究

Study on the current status and related factors of depression in human immunodeficiency virus infection/acquired immunodeficiency syndrome patients with drug resistance to antiretroviral therapy

作者：邓婉露李曼王瑞蒙李梅彭芳新

英文作者：Deng Wanlu Li Man Wang Rui Meng Limei Peng Fangxin

单位：空军军医大学唐都医院传染病科，西安710038

英文单位：Department of Infectious Diseases Tangdu Hospital Air Force Medical University Xi′an 710038 China

关键词：抗反转录病毒治疗；人类免疫缺陷病毒；获得性免疫缺陷综合征；抑郁症

英文关键词：Antiretroviraltherapy;Humanimmunodeficiencyvirus;Acquiredimmunodeficiencysyndrome;Depression

• 摘要：

• 目的  研究对抗反转录病毒治疗（ART）耐药的人类免疫缺陷病毒（HIV）感染/获得性免疫缺陷综合征（AIDS）患者（以下简称HIV/AIDS患者）合并抑郁症的现状，并分析其相关影响因素。方法 回顾性选取2021年8月至2025年8月在空军军医大学第二附属医院就诊的对ART耐药的118例HIV/AIDS患者作为研究对象。根据是否并发抑郁症将患者分为非抑郁症组（90例）和抑郁症组（28例）。比较2组患者的临床特征。采用多因素Logistic回归模型分析对ART耐药的HIV/AIDS患者合并抑郁症的影响因素，构建并验证预测模型。结果 2组患者文化程度、酗酒史、婚姻状况、病程、合并高血压病、社会支持度、病耻感、血小板计数比例、血红蛋白、总胆红素水平比较，差异均有统计学意义（均P＜0.05）。多因素Logistic回归分析结果显示病程＞5年、病耻感高、血小板计数＜100×109/L均是对ART耐药的HIV/AIDS患者合并抑郁症的独立危险因素，而社会支持度高是独立保护因素（均P＜0.05）。受试者工作特征曲线分析结果显示该预测模型判断对ART耐药的HIV/AIDS患者合并抑郁症的曲线下面积为0.905，敏感度为89.3%，特异度为75.6%。结论 对ART耐药的HIV/AIDS患者存在抑郁风险，其发生与患者病程、病耻感、血小板计数及社会支持度相关，据此构建的风险预测模型有助于判断抑郁症风险。

• Objective To investigate the current status of depression in human immunodeficiency virus infection/acquired immunodeficiency syndrome (HIV/AIDS) patients (hereinafter referred to as HIV/AIDS patients) with drug resistance to antiretroviral therapy (ART), and analyze its related influencing factors. Methods A total of 118 HIV/AIDS patients with ART resistance admitted to the Second Affiliated Hospital of Air Force Medical University from August 2021 to August 2025 were retrospectively selected as research subjects. According to the complication of depression, the patients were divided into non-depression group (90 cases) and depression group (28 cases). The clinical characteristics were compared between the two groups. Multivariate Logistic regression model was adopted to analyze the influencing factors of depression in HIV/AIDS patients with ART resistance, and the prediction model was constructed and validated. Results There were statistically significant differences in educational level, history of alcohol abuse, marital status, disease course, complicated hypertension, social support level, stigma, platelet count proportion, hemoglobin and total bilirubin levels between the two groups (all P＜0.05). Multivariate Logistic regression analysis showed that disease course more than 5 years, high stigma and platelet count less than 100×109/L were independent risk factors for depression in HIV/AIDS patients with ART resistance, while high social support was an independent protective factor (all P＜0.05). Receiver operating characteristic curve analysis showed that the area under the curve, sensitivity and specificity of the prediction model for judging depression in HIV/AIDS patients with ART resistance were 0.905, 89.3% and 75.6% respectively. Conclusion HIV/AIDS patients with ART resistance are at risk of depression, which is correlated with disease course, stigma, platelet count and social support level. The risk prediction model constructed accordingly is helpful for evaluating the risk of depression.