2026 年第 10 期 第 21 卷

宫颈癌组织中相关指标水平与肿瘤进展及临床生存期的相关性分析

Correlation analysis of related index levels with tumor progression and clinical survival time in cervical cancer tissues

作者：杨玉滢1周燕玲1刘璐2杜蓉1

英文作者：Yang Yuying1 Zhou Yanling1 Liu Lu2 Du Rong1

单位：1新疆医科大学第一附属医院妇科，乌鲁木齐830000；2新疆医科大学公共卫生学院儿少卫生与妇幼保健学教研室，乌鲁木齐830000

英文单位：1Department of Gynecology the First Affiliated Hospital of Xinjiang Medical University Urumqi 830000 China; 2Teaching and Research Office of Child and Adolescent Health and Maternal and Child Health Care of the School of Public Health Xinjiang Medical University Urumqi 830000 China

关键词：宫颈癌；甘油-3-磷酸脱氢酶2；脂滴调节极低密度脂蛋白装配因子1

英文关键词：Cervicalcancer;Glycerol-3-phosphatedehydrogenase2;Adiposedropletassemblyfactor1

• 摘要：

• 目的  研究宫颈癌组织中甘油-3-磷酸脱氢酶2(GPD2)和脂滴调节极低密度脂蛋白装配因子1(AUP1)表达，分析二者与肿瘤进展及临床生存期的关系。方法 收集2020年2月至2022年2月新疆医科大学第一附属医院诊治的122例宫颈癌患者。检测癌组织及癌旁组织GPD2和AUP1 mRNA表达，GPD2和AUP1蛋白表达，分析相关性。随访并通过Kaplan-Meier曲线评价生存预后，采用Cox回归方法 分析影响宫颈癌预后的因素。结果 癌组织中GPD2 mRNA、AUP1 mRNA表达高于癌旁组织［（3.02±0.42）比（1.08±0.23）、（2.87±0.32）比（0.98±0.26）］，GPD2、AUP1阳性率亦高于癌旁组织（均P<0.05）。宫颈癌组织中GPD2 mRNA与AUP1 mRNA表达呈正相关，GPD2蛋白与AUP1蛋白表达亦呈正相关（均P<0.001）。随访中进展29例，3年无进展生存率为76.2%（93/122）。GPD2、AUP1阳性组3年无进展生存率为70.0%(56/80)、70.7%(58/82)，低于GPD2、AUP1阴性组的88.1%(37/42)、87.5%(35/40)，差异均有统计学意义（均P<0.05）。多因素Cox回归分析结果显示，国际妇产科联盟分期Ⅲ期、GPD2阳性、AUP1阳性均为影响宫颈癌预后的危险因素（风险比=1.547、1.654、1.443，均P<0.05）。结论 宫颈癌GPD2、AUP1表达升高，均参与宫颈癌肿瘤进展，可作为新的宫颈癌预后评估的标志物。

• Objective To investigate the expression of glycerol-3-phosphate dehydrogenase 2 (GPD2) and adipose droplet assembly factor 1 (AUP1) in cervical cancer tissues, and to analyze their correlations with tumor progression and clinical survival time. Methods A total of 122 patients with cervical cancer treated in the First Affiliated Hospital of Xinjiang Medical University from February 2020 to February 2022 were enrolled. The mRNA and protein expressions of GPD2 and AUP1 in cervical cancer tissues and adjacent normal tissues were detected, and their correlations were analyzed. Survival prognosis was evaluated by Kaplan-Meier curve during follow-up, and Cox regression model was used to analyze prognostic factors of cervical cancer. Results The mRNA expressions of GPD2 and AUP1 in cancer tissues were higher than those in adjacent tissues ［(3.02±0.42) vs (1.08±0.23), (2.87±0.32) vs (0.98±0.26)］, and the positive rates of GPD2 and AUP1 protein were also higher than those in adjacent tissues (all P<0.05). The mRNA expression of GPD2 was positively correlated with AUP1 mRNA expression, and GPD2 protein expression was positively correlated with AUP1 protein expression in cervical cancer tissues (all P<0.001). During follow-up, 29 cases experienced disease progression, and the 3-year progression-free survival rate was 76.2%(93/122). The 3-year progression-free survival rates in GPD2-positive group and AUP1-positive group were 70.0%(56/80) and 70.7%(58/82) respectively, which were lower than 88.1%(37/42) and 87.5%(35/40) in the corresponding negative groups (both P<0.05). Multivariate Cox regression analysis showed that International Federation of Gynecology and Obstetrics Stage Ⅲ, GPD2 positivity and AUP1 positivity were independent risk factors affecting the prognosis of cervical cancer (hazard ratio=1.547, 1.654, 1.443, all P<0.05). Conclusions The upregulated expression of GPD2 and AUP1 in cervical cancer is involved in tumor progression, which can serve as novel biomarkers for prognostic evaluation of cervical cancer.